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The CTC collaborates with the Australian Genomic Cancer Medicine Centre (AGCMC) to conduct clinical trials to improve personalised cancer treatment access and outcomes for patients with rare or advanced cancers.
One in five cancers is diagnosed rare. There are few trials available for these cancers and limited funding for treatments compared to common cancers.By exploring changes in cancer genes/proteins, we have the power to personalise treatment according to genes/proteins and not the cancer type.
The Molecular Screening and Therapeutics Study (MoST) will:
This ground-breaking program has already enrolled more than 1,000 Australians with advanced cancers, more than 80% of which are rare and less common.
The MoST protocol is also conducting clinical studies to test new immunotherapy drugs in patients with high-mortality cancers. Although immunotherapies are proving to be effective in many cancer types, they do not work in all patients. We are looking to find biomarkers that can predict which patients will benefit from specific treatments targeting the immune system, and to better understand how immunotherapies work to fight cancer.