Research Themes



BSc (Med) (hons I), University of Sydney MB BS (hons I), University of Sydney SM (Master of Science in Biostatistics), Harvard University FRACP MD 'Cancer clinical trials: statistical clinical and ethical issues', University of Sydney

Prof John Simes AO

Co-Director, Cancer Trials

Professor John Simes AO is a Senior Principal Research Fellow, he was the Founding Director of the NHMRC Clinical Trials Centre and is currently Co-Director of Cancer Trials.

John is a leading international researcher in clinical trials, particularly in cancer, cardiovascular disease, diabetes and neonatal medicine. From 1988 to 2021, John co-led the NHMRC Clinical Trials Centre collaborating with clinical investigators and other researchers nationally and internationally in a research program aimed at improving health practice and health outcomes through better use of clinical trials research. He has contributed to over 300 peer-reviewed articles, with many having a significant impact on current knowledge and clinical practice.

John is a founding member of the Australian Clinical Trials Alliance (ACTA), formed in 2012 to promote effective and evidence based healthcare in Australia through investigator-initiated clinical trials. He is a practising medical oncologist in neuro-oncology at Royal Prince Alfred Hospital and the Chris O'Brien Lifehouse and is Professor of Clinical Epidemiology, Faculty of Medicine, University of Sydney. He has taught medical students and postgraduate students at the University of Sydney since 1989.

John was awarded the Cancer Achievement Award for lifetime achievement in oncology by the Medical Oncology Group of Australia (2010) and the Distinguished Harvard Alum Award (Biostatistics) from Harvard University (2009) in recognition of his work in research. He is a Fellow of the Australian Academy of Health and Medical Sciences and a member of research committees, trials groups and boards, including cancer cooperative groups and safety and data monitoring committees. He was named on the Clarivate Analytics 2018 Highly Cited Researchers List for 2018. In 2020, he received an Order of Australia award (AO) for his service to education and medicine in cancer research and clinical trials. 

Committee Memberships:

  • Australian Clinical Trials Alliance boardNHMRC CTC Research Committee
  • ANZ Clinical Trials Registry Advisory Committee
  • Management Committee, Long-term Intervention with Pravastatin in Ischaemic Disease (LIPID)
  • Management Committee and Executive, Fenofibrate Intervention and Event Lowering in Diabetes (FIELD)
  • Joint coordinator, Cholesterol Treatment Trialists Collaboration (CTTC)
  • Steering Committee chair, International Trials of Aspirin to Prevent Recurrent Venous Thrombo-embolism (INSPIRE)
  • Safety and Data Monitoring Committee, Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)
  • Scientific Advisory Committee, ANZ Breast Cancer Trials Group (ANZBCTG)
  • Scientific Advisory Committee, Australasian Gastro-Intestinal Trials Group (AGITG) (group coordinator since 2002)
  • Scientific Advisory Committee, Cooperative Trials Group for Neuro-Oncology (COGNO) (deputy chair)
  • Trial Management Committee, Sentinel Biopsy versus Axillary Clearance trial (SNAC)
  • Trial Management Committee, Aspirin to Prevent Recurrent Venous Thrombo-embolism (ASPIRE) (chair)
  • Trial Management Committee, Benefits Of Oxygen Saturation Targeting (BOOST II)
  • Trial Management Committee, Lactoferrin Infant Feeding Trial (LIFT)
  • Trial Management Committee, Individualised Molecular Pancreatic Cancer Therapy (IMPACT) (co-chair)


View John's publications.