Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy (the GAME trial).

This randomised control trial aims to evaluate the effects of an infant-friendly motor training, parent coaching and environmental enrichment program known as GAME versus traditional early intervention for infants with cerebral palsy to assess if early brain training delivers any additional benefits over and above standard care.

See ANZCTR for full trial details >


Trial aim:

Address the question: "From the perspective of the Australian government, is the GAME intervention for newly diagnosed infants with cerebral palsy, less than 6 months of age, cost-effective compared with standard care early interventions?”

The primary objective is to calculate the within-trial cost-effectiveness of the GAME intervention versus standard care in the first 2 years of life


Infants aged 3-6.5 months (by calendar date) discharged home from hospital and having either a diagnosis of cerebral palsy or diagnosis of “high risk of cerebral palsy” according to International Guidelines for Accurate Early Detection

Trial area:

New South Wales, Victoria, Queensland and Western Australia


Cerebral Palsy Alliance, University of Sydney, Children’s Hospital Westmead, University of Queensland, Children’s Health Research Centre, Murdoch Children’s Research Institute, Monash Medical Centre

Funded by:

NHMRC project funding #APP1120031

Chief investigators:

Rachael L Morton, Anh Tran, Adrienne Kirby, Iona Novak, Cathy Morgan, Nadia Badawi, Ros Boyd, Alicia Spittle, Russell Dale, Rod Hunt, Koa Whittingham, Kerstin Pannek, Andrea Guzetta, Claire Galea, Karen Walker, Kristina Prelog, Michael Fahey, Shannon Clough, Stephen Rose, William Tarnow-Mordi, Catherine Elliott, Jane Valentine, Lauren Caleo

Trial registration number: