The Centre of Research Excellence in the Early Prevention of Obesity in Childhood (EPOCH CRE) aims to reduce the prevalence of obesity and obesity-related behaviours in the first five years of life, and their future impact.

The NextGen team at the CTC lead Stream 1 of the CRE, with the primary objectives of:

  1. Determining effects of early intervention programs which are aimed at preventing childhood obesity at 2 years of age
  2. Determining the longer term effects – at 3.5 and 5 years of age – of early intervention programs in Australasia
  3. Determining which components of the complex interventions tested are more or less effective in preventing childhood obesity, and which interventions work best for which subgroups.
  4. Establishing a framework for data sharing and collaborative analyses of early childhood obesity prevention trials worldwide. This has led to the formation of the TOPCHILD Collaboration.



NHMRC Clinical Trials Centre, University of Sydney, Deakin University, Flinders University, Queensland University of Technology, University of Otago

Chief Investigators:

Anna Lene Seidler, Kylie Hunter, Lisa Askie , Louise Baur, Chris Rissel, Karen Campbell, Kylie Hesketh, Rachael Taylor, Alison Hayes, Marj Moodie, Li Ming Wen, Lynne Daniels, Anthea Magarey

Trial Reg no.:




External website:


NHMRC Project Grant (ID: 1028555)

NHMRC Centre of Research Excellence (ID: 1101675)

CTC staff involved:

Anna Lene Seidler, Kylie Hunter, David Espinoza, Andrew Martin, Lisa Askie


  1. Brown V, Moodie M, Sultana M, Hunter KE, Byrne R, Seidler AL, Golley R, Taylor RW, Hesketh KD, Matvienko-Sikar K. Core outcome set for early intervention trials to prevent obesity in childhood (COS-EPOCH): Agreement on “what” to measure. International Journal of Obesity. 2022 Aug 4:1-8.
  2. Seidler AL, Hunter KE, Baur L, Espinoza D, Taylor RW, Wen LM, Hesketh KD, Campbell K, Daniels L, Mihrshahi S, Rissel C. Examining the sustainability of effects of early childhood obesity prevention interventions: Followup of the EPOCH individual participant data prospective meta Pediatric Obesity. 2022 Apr 8:e12919.
  3. Mihrshahi S, Jawad D, Richards L, Hunter KE, Ekambareshwar M, Seidler AL, Baur LA. A Review of Registered Randomized Controlled Trials for the Prevention of Obesity in Infancy. International Journal of Environmental Research and Public Health. 2021; 18(5):2444.
  4. Seidler AL, Hunter K, Espinoza D, Mihrshahi S, Askie L. Quantifying the advantages of conducting a prospective meta-analysis (PMA): a case study of early childhood obesity prevention. Trials. 2021; 22(1):1-8.
  5. Askie LM, Espinoza D, Martin A, Daniels LA, Mihrshahi S, Taylor R, Wen LM, Campbell K, Hesketh KD, Rissel C, Taylor B, Magarey A, Seidler AL, Hunter KE, Baur LA. Interventions commenced by early infancy to prevent childhood obesity—The EPOCH Collaboration: An individual participant data prospective meta‐analysis of four randomized controlled trials. Pediatric Obesity 2020; 15(6).
  6. Seidler AL, Hunter K, Johnson B, Ekambareshwar M, Taki S, Mauch C, Mihrshahi S, Askie L, Campbell KJ, Daniels L, Taylor RW, Wen LM, Byrne R, Lawrence J, Perlstein R, Wardle K, Golley R. Understanding, comparing and learning from the four EPOCH early childhood obesity prevention interventions: A multi-methods study. Pediatric Obesity 2020; e12679.
  7. Askie LM, Baur LA, Campbell K, Daniels LA, Hesketh K, Magarey A, Mihrshahi S, Rissel C, Simes J, Taylor B, Taylor R, Voysey M, Wen LM, on behalf of the EPOCH Collaboration. The Early Prevention of Obesity in CHildren (EPOCH) Collaboration - an Individual Patient Data Prospective Meta-Analysis. BMC Public Health 2010; 10, 728.