ASPiRATION – An observational cohort study to assess the clinical impact of comprehensive genomic profiling in metastatic lung cancer patients.

Lung cancer is the leading cause of cancer death in Australia and worldwide, with a five-year survival rate of only 17 per cent.

The ASPiRATION program is a pioneering 5-way partnership between Government, industry, and academia. The program is led by the Thoracic Oncology Group of Australasia (TOGA) [and formerly the Australasian Lung Cancer Trials Group (ALTG)], in collaboration with the Australian Genomic Cancer Medicine Centre (AGCMC) and the NHMRC Clinical Trials Centre (CTC).

The program is jointly funded by the federal government’s Medical Research Future Fund (MRFF) and Roche, as well as in-kind support through access to Roche medicines in 4 of the program’s therapeutic clinical trials.

The ASPiRATION study is the first of its kind in Australia to generate high-quality, real-world data about the impact and value of comprehensive genomic profiling (CGP) to deliver precision medicine and personalised healthcare, by identifying actionable molecular targets and treating these patients in a suite of therapeutic substudies using novel targeted treatments.

Molecular screening for ASPiRATION commenced in late 2020. Five therapeutic substudies opened in 2021, and a sixth related clinical trial started in 2022, all developed in partnership between TOGA and CTC, and supported by funding and in-kind support through access to medicines from various industry partners.

See ACTRN for full trial details >


Trial Summary:

To investigate the clinical impact of comprehensive genomic profiling (CGP) on the management of metastatic non-squamous non-small cell lung cancer (mNSCLC) and assess the feasibility of CGP implementation nationally.

Supported By:

Australian Government (MRFF) & Roche


Patients with pathologically confirmed mNSCLC, ECOG performance status 0-1 and sufficient tissue for molecular screening.

Registration ID:






Activation Date:

Dec 2020


Prof Nick Pavlakis, Royal North Shore Hospital

Prof Ben Solomon, Peter MacCallum Cancer Centre