Pilot and definitive randomised double-blind placebo-controlled trial evaluating an oral cannabinoid-rich THC/CBD cannabis extract for secondary prevention of chemotherapy-induced nausea and vomiting.

 

Results

Results published in Annals of Oncology found a significant improvement in the control of chemotherapy-induced nausea and vomiting. A quarter of the patients taking medicinal cannabis experienced no vomiting and nausea, compared to 14 per cent of people who took a placebo.

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View editorial >

 

Overview

Trial summary:

This trial aims to determine if an anti-emetic regimen incorporating oral tetra-hydrocannabinol (THC)/ cannabidiol (CBD) is more effective than a guideline-consistent anti-emetic regimen for the secondary prevention of chemotherapy-induced nausea and vomiting (CINV), during 3 consecutive cycles of chemotherapy.

View the lay summary.

Supported By:

NSW Health, NHMRC Clinical Trials Centre (USYD) and Tilray

Eligibility:

Patients aged ≥18 years with known malignancy of any stage, requiring  ≥ 2 further cycles of moderate to highly emetogenic intravenous chemotherapy and experiencing significant CINV during previous cycles

Objectives:

To compare, amongst patients randomised to oral THC/CBD or placebo, the ability to control emesis and nausea

Registration ID:

ACTRN12616001036404

Participation:

Australia

Australian Lead Group:

NHMRC Clinical Trial Centre (USYD)

In collaboration with Chris O’Brien Lifehouse and the Lambert Initiative for Cannabinoid Therapeutics (USYD)

Status:

Recruiting

Activation Date:

16 September 2016 (HREC Approval)

Chairs:

Clinical Associate Professor Peter Grimison

Contact:

cannabisCINV.study@sydney.edu.au

 

See ANZCTR for full trial details >