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Title: A single-arm, open-label, phase II trial of entrectinib in patients with advanced tumours harbouring NTRK fusions or ROS1 gene rearrangements detected by comprehensive genomic profiling.
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Trial Summary: |
The aim of this ASPiRATION and MoST substudy to assess the clinical activity of entrectinib in adult patients with advanced cancers harbouring NTRK or ROS1 gene alterations. |
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Supported By: |
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Eligibility: |
Adult patients with advanced cancers harbouring NTRK fusions or ROS1 gene rearrangements. NSCLC patients with ROS1 gene alterations must be FISH-negative, i.e. not eligible for reimbursed ROS1-targeted treatment. |
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Registration ID: |
ACTRN12621000284864 |
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Participation: |
National |
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Status: |
Closed |
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Activation Date: |
21/05/2021 |
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Chairs: |
Dr Peey-Sei Kok, A/Prof Tom John, and Dr Subotheni Thavaneswaran |
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Contact: |