Research Themes

Oncology

Qualifications

BSocSci (Hons) MPH DipMan DipBus

Burcu Vachan

Director, Clinical Trial Operations

With a background in psychology and research methodology and commencing her cancer research career at Westmead Hospital (Breast Cancer Institute and then Radiation Oncology) Burcu joined the CTC in 2002. Since then she has led the Oncology Program consisting of approximately 40 trials staff members working with national and international collaborative groups on multi-disciplinary and multicentre clinical trials in cancer.

In 2007, Burcu spent 10-months at the Clinical Trials Group of Canada (CTG), based in Queens University in Kingston Ontario, supported by an International Research Fellowship granted by the Cancer Institute NSW. Her projects included looking at ways to increase international collaboration in clinical trials.

During her long service leave in 2013 Burcu participated in a Strategic Leadership Program at Stanford University, California. Returning to the CTC in 2014 Burcu used what she learnt during this immersive on campus experience to lead the restructure of the Oncology Program introducing specialised roles in Development and Operations and specific support in start-up activities as they relate to the centralisation of multi-site ethics approvals.

Since 2018 Burcu has been in the role of Head Clinical Trial Operations supporting the program leads working across the therapeutic areas of cardiovascular, diabetes and neonatal research in addition to the cancer program.

Burcu’s interests are in process improvement, innovation and leadership. She is passionate about working with her talented team on introducing mechanisms to continue to deliver on high quality clinical trials in academia.

 

Publications

Vachan, Burcu (2012) Applying project management principles to research projects in a health setting, The Radiographer. 59(1): 5-7. Book chapter. Flow of participants in randomised studies in Interpreting and Reporting Clinical Trials: A guide to the CONSORT statement and the principles of randomized controlled trials. Chapter 11, p. 72-78 Eds. Keech A, Gebski V, Pike R, Australasian Medical Publishing Company, Sydney 2007.

Veness MJ. Foroudi F. Gebski V. Timms I. Sathiyaseelan Y. Cakir B. Tiver KW. Use of topical misoprostol to reduce radiation-induced mucositis: results of a randomized, double-blind, placebo-controlled trial. Australasian Radiology. 50(5):468-74, 2006 Oct.

Brand AH, Bull CA, Cakir B. (2006) Vaginal stenosis in patients treated with radiotherapy for carcinoma of the cervix. International Journal of Gynecological Cancer; 16: 288-293.

Foo K. Gebski V. Yeghiaian-Alvandi R. Foroudi F. Cakir B. Outcome following radiotherapy for loco-regionally recurrent non-small cell lung cancer. Australasian Radiology. 49(2):108-12, 2005 Apr.

Chin YS, Jayamohan J, Clouston P, Gebski V, Cakir B. (2004) Driving and patients with brain tumours: a postal survey of neurosurgeons, neurologists and radiation oncologists. Journal of Clinical Neuroscience; 11(5): 471–474.

Veness, M., Palme, C., Smith, M., Cakir, B., Morgan, G. and Kalnins, I. (2003) Cutaneous Head and Neck Squamous Cell Carcinoma Metastatic to Cervical Lymph Nodes (Nonparotid): A Better Outcome with Surgery and Adjuvant Radiotherapy, The Laryngoscope, Vol. 113. pp. 1827-1833.

Bell, C. and Cakir, B. (2003) The Results of an Australian and New Zealand Survey on the Current Practice of Chest Immobilisation during Radiation Therapy, The Radiographer, Vol. 50, pp. 73-77.

Dona,E., Veness, M., Cakir, B. and Morgan, G. (2003) Metastatic Cutaneous Squamous Cell Carcinoma to the Parotid: The Role of Surgery and Adjuvant Radiotherapy to Achieve Best Outcome, ANZ J. Surgery, Vol. 73, pp. 692-696.

Babington, S., Veness, M., Cakir, B., Gebski, V., Morgan, G. (2003) Squamous Cell Carcinoma of the Lip: Is there a role for adjuvant radiotherapy in improving local control following incomplete or inadequate excision?, ANZ J. Surgery, Vol. 73, pp. 621-625.

Cakir, B., Gebski, V. and Keech, A. (2003) Flow of participants in randomised studies, Medical Journal of Australia, Vol. 178., pp. 347-349.

De Morgan, S., Redman, S., White, K., Cakir, B., Boyages, J. (2002) ‘Well, have I got cancer or haven’t I?’ The psycho-social issues for women diagnosed with ductal carcinoma in situ, Health Expectations, Vol. 5, 310-318.

Chua, M., Veness, M., Morgan, G., Shakespeare, T., Hehir, A., Gebski, V., Cakir, B., Tiver, K. Parotid lymph-node metastases from cutaneous squamous-cell carcinomas: Treatment outcome and prognostic factors following surgery and adjuvant radiotherapy, Australasian Radiology (2002) 46, 174-179.

Kneebone A. Turner S. Berry M. Cakir B. Gebski V. Australian prostate-specific antigen outcome and toxicity following radiation therapy for localized prostate cancer. Australasian Radiology. 47(4):422-7, 2003 Dec.

Foo K. Gebski V. Yeghiaian-Alvandi R. Foroudi F. Cakir B. Outcome following radiotherapy for loco-regionally recurrent non-small cell lung cancer. Australasian Radiology. 49(2):108-12, 2005 Apr.

Veness, M., Ong, C., Cakir, B. and Morgan, G. Squamous cell carcinoma of the lip. Patterns of relapse and outcome: Reporting the Westmead Hospital experience, 1980 – 1997, Australasian Radiology (2001) 45, 195–199.

Francis M, Cakir B, Bilous M, Ung O, Boyages J. Conservation Surgery and Radiation Therapy for Invasive Lobular Carcinoma of the Breast, Australian and New Zealand Journal of Surgery (1999) 69, 450–454.

Francis M, Cakir B, Gebski V, Ung O, Boyages J. Prognosis after Breast Recurrence Following Conservation Surgery and Radiotherapy in Node-Negative Breast Cancer, British Journal of Surgery (1999) 86, 1556–1562.



Posters

Vachan, B., and the CTC Cooperative Group Working Party. Cancer Cooperative Trials Groups & the CTC – A Model for Successful Trial Conduct. Poster at ACTA Symposium 2017, Sydney.

Vachan, B., Hague, W., Gebski, V. ‘If you build it they will come’, Is Predicting Recruitment to Clinical Trials a Field of Dreams? Poster at ACTA Symposium 2017, Sydney.

Pike, R. Sjoquist, K.M. Vachan, B. Sharing results of clinical trials with trial participants: an online solution. Poster at ACTA Symposium 2017, Sydney.

Silvester, S.J. Hague, W. Maclean, M. Vachan, B.‘Minimum time/maximum quality’: Automated tracking systems to improve efficiency, reduce the risk of human error and ensure timely data collection. Society of Clinical Trials Conference, 2015, Washington USA.

Mister, R. Scott, K. Smith, P. Vachan, B. Hague, W. Streamlining ethics applications since 2007: the CTC experience. Poster at ACTA Symposium 2017, Sydney.

Karapetis C, Khambata-Ford S, Jonker D, O’Callaghan C, Tu D, Vachan B, Simes J, Langer C, Moore M, Zalcberg J. Evaluation of KRAS Mutation Status and Amphiregulin and Epiregulin Gene Expression as Predictive Biomarkers for Benefit from Cetuximab in the Treatment of Advanced Colorectal Cancer – Results from NCIC CTG CO.17: A Phase III Trial of Cetuximab versus Best Supportive Care. Poster at the European Society of Medical Oncology (ESMO) Meeting, September 2008.

O’Callaghan C, Tu D, Karapetis C, Au H, Moore M, Zalcberg, J, Trudeau M, Yip D, Vachan B, Jonker D. The relationship between the development of rash and clinical and quality of life outcomes in colorectal cancer patients treated with cetuximab in NCIC CTG CO.17. Poster at the American Society of Clinical Oncology (ASCO) Meeting, Chicago, June 2008.

Niazi, T., Cakir, B., Brundage, M., Parulekar, W., Parliament, M. A Review of Quality Assurance Including Real Time Review in Trials Involving Radiotherapy. Poster presented at the Society of Clincial Trials Meeting, Montreal 2007.

Agustin, C. and Cakir, B. The Results of an Australian and New Zealand Survey on the Current Practice of Chest Immobilisation During Radiation Therapy (poster), 12th ISRRT World Congress, Amsterdam, 2002 (won 1st prize).

Ahern, V. and Cakir, B. Patterns of Practice in Paediatric Radiotherapy in Australia and New Zealand (poster), SIOP XXXIII Meeting, Brisbane, October 2001.

Cakir, B. Utilising Stratified Minimisation Randomisation in the Study of Misoprostol for Radiation Mucositis. AHR~DMA 9th Annual Scientific Meeting, Sydney Hilton Hotel, 1999 (Won first prize in the Oncology Division).

Francis M, Cakir B, Bilous M, Ung O, Boyages J. Conservation Surgery and Radiation Therapy for Invasive Lobular Carcinoma of the Breast. Abstract presented at the Annual Australasian Society for Breast Diseases Conference, Gold Coast, September 1998.